VP, Biology and Translational Research

  • Competitive
  • Milpitas, United States
  • Permanent

Job Title: VP, Biology and Translational Research

Location: East Bay Area, CA - 4-5x onsite per week

Position Summary:

Our client, a leading biotechnology firm, is seeking an entrepreneurial, strategic, driven, and visionary scientific leader to join their team as VP, Biology and Translational Research. Reporting to the EVP, Chief Drug Discovery and Pre-clinical Development Officer, this role is critical to the R&D Leadership Team. The VP will be instrumental in building a discovery pipeline to develop best-in-class medicines and new modalities. This leader will guide the biology team through state-of-the-art scientific innovation, strategy, and operations to continuously develop and expand the technology platform, leading to new clinical candidates.

Key Responsibilities:

  • Leadership and Team Building:

    • Lead the discovery biology team responsible for target identification, discovery, and pre-clinical development leading to new clinical candidates.
    • Build and lead a discovery biology group, including creating a high-throughput discovery engine.
    • Provide creative and innovative leadership of discovery biology, translating biological hypotheses into transformative medicines.
    • Build and lead a strong team of directors, scientists, and RAs to achieve company milestones.
    • Ensure effective interaction and communication between Biology, Chemistry, and DMPK Strategy teams, in alignment with the leadership team.
    • Expand the company's external network of advisors and establish deep domain area expertise in program areas such as immunology/inflammation and hematology.
  • Research and Development:

    • Design and lead research and drug discovery projects, including related discovery biology, biochemistry, protein sciences, and cell biology.
    • Direct the creation of various in vitro assays and assist with in vivo models and pharmacology experiments in support of program objectives.
    • Collaborate closely with Chemistry and DMPK groups to drive discovery, lead optimization, and pre-clinical characterization of multiple candidates across different discovery programs.
    • Communicate discovery strategy and progress to executive management, the scientific board of directors, and external partners.
  • Budget and Resource Management:

    • Construct and manage spending budgets and project resourcing.
    • Keep up to date with the latest scientific advances, technologies, and trends in hematology, immunology research, and development to deliver the next generation of therapies.

Basic Qualifications:

  • A Ph.D. in Biology, Biochemistry, Cell Biology, or a related field.
  • 15+ years of biotechnology and pharmaceutical drug discovery R&D experience.
  • Demonstrated expertise and a track record of success in advancing discovery programs from target validation through lead optimization and into early clinical development.
  • Proven track record in target discovery and validation, cell biology, assay and model development, and biomarkers across therapeutic areas and target classes.
  • Strong focus on using new cutting-edge technologies to drive deep mechanistic insights into disease biology.
  • Therapeutic domain expertise in hematology, immunology, and metabolic  diseases.
  • Experience with advanced peptide display technologies such as phage display and mRNA display. Experience with DNA-encoded libraries for drug discovery is a plus.
  • Extensive experience in CRO management of drug discovery programs.
  • Highly engaged, self-starter with a creative, proactive, and communicative approach.
  • Excellent leadership capabilities with experience guiding and motivating successful teams.
  • Strong communication and partnering skills, including the identification of new collaboration opportunities and conducting due diligence.
  • A publication record in top-tier, peer-reviewed journals is highly desirable.

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